Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC2903443 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100601 12
The modular nature of nicotinamide adenine dinucleotide (NAD)-mimicking inosine monophsophate dehydrogenase (IMPDH) inhibitors has prompted us to investigate novel mycophenolic adenine dinucleotides (MAD) in which 1,2,3-triazole linkers were incorporated as isosteric replacements of the pyrophosphate linker. Synthesis and evaluation of these inhibitors led to identification of low nanomolar inhibitors of human IMPDH and more importantly the first potent inhibitor of IMPDH from Mycobacterium tube ...[more]