Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC2904325 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Liu Wanli W Meckel Tobias T Tolar Pavel P Sohn Hae Won HW Pierce Susan K SK
Immunity 20100601 6
Memory B cells express high-affinity, immunoglobulin GB cell receptors (IgG BCRs) that enhance B cell responses, giving rise to the rapid production of high-affinity, IgG antibodies. Despite the central role of IgG BCRs in memory responses, the mechanisms by which the IgG BCRs function to enhance B cell responses are not fully understood. Using high-resolution live-cell imaging, we showed that IgG1 BCRs dramatically enhanced the earliest BCR-intrinsic events that followed within seconds of B cel ...[more]