Ontology highlight
ABSTRACT:
SUBMITTER: Ramadori G
PROVIDER: S-EPMC2904327 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Ramadori Giorgio G Fujikawa Teppei T Fukuda Makoto M Anderson Jason J Morgan Donald A DA Mostoslavsky Raul R Stuart Ronald C RC Perello Mario M Vianna Claudia R CR Nillni Eduardo A EA Rahmouni Kamal K Coppari Roberto R
Cell metabolism 20100701 1
Feeding on high-calorie (HC) diets induces serious metabolic imbalances, including obesity. Understanding the mechanisms against excessive body weight gain is critical for developing effective antiobesity strategies. Here we show that lack of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 in pro-opiomelanocortin (POMC) neurons causes hypersensitivity to diet-induced obesity due to reduced energy expenditure. The ability of leptin to properly engage the phosphoinositide 3- ...[more]