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Measurement of mismatch negativity in individuals: a study using single-trial analysis.

ABSTRACT: Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t-test with an index of inter-trial coherence, giving significant MMN in 14 (82%) of individuals. Single-trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli.

SUBMITTER: Bishop DV

PROVIDER: S-EPMC2904495 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Measurement of mismatch negativity in individuals: a study using single-trial analysis.

Bishop D V M DV Hardiman M J MJ

Psychophysiology 20100222 4

Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standar ...[more]

PMID: 20210877

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Project description:BackgroundIn the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone to develop psychosis. Although the transition rate to psychosis in individuals at UHR is 10% to 30% within several years, some individuals at UHR present with poor prognoses even without transition occurring. Therefore, it is important to identify biomarkers for predicting the prognosis of individuals at UHR, regardless of transition. We investigated whether mismatch negativity (MMN) in response to both duration deviant stimuli (dMMN) and frequency deviant stimuli (fMMN) could predict prognosis, including remission and neurocognitive function in individuals at UHR.Materials and methodsIndividuals at UHR (n = 24) and healthy controls (HC; n = 18) participated in this study. In an auditory oddball paradigm, both dMMN and fMMN were measured at baseline. Remission and neurocognitive function after > 180 days were examined in the UHR group. Remission from UHR was defined as functional and symptomatic improvement using the Global Assessment of Functioning (GAF) score and Scale of Prodromal Symptoms (SOPS) positive subscales. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia (BACS). We examined differences in MMN amplitude at baseline between those who achieved remission (remitters) and those who did not (non-remitters). Multiple regression analyses were performed to identify predictors for functioning, positive symptoms, and neurocognitive function.ResultsCompared with the HC group, the UHR group had a significantly attenuated dMMN amplitude (p = 0.003). In the UHR group, GAF scores significantly improved during the follow-up period (mean value 47.1 to 55.5, p = 0.004). The dMMN amplitude at baseline was significantly larger in the remitter (n = 6) than in the non-remitter group (n = 18) (p = 0.039). The total SOPS positive subscale scores and fMMN amplitude at baseline could predict BACS attention subscore at the follow-up point (SOPS positive subscales, p = 0.030; fMMN, p = 0.041).ConclusionOur findings indicate that dMMN and fMMN predicted remission and neurocognitive function, respectively, in individuals at UHR, which suggests that there are both promising biomarker candidates for predicting prognosis in individuals at UHR.

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Measurement of mismatch negativity in individuals: a study using single-trial analysis.

Publications

Measurement of mismatch negativity in individuals: a study using single-trial analysis.

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