Ontology highlight
ABSTRACT:
SUBMITTER: Poulain P
PROVIDER: S-EPMC2904573 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Journal of computational chemistry 20081101 15
Coarse grain modelling of macromolecules is a new approach, potentially well adapted to answer numerous issues, ranging from physics to biology. We propose here an original DNA coarse grain model specifically dedicated to protein-DNA docking, a crucial, but still largely unresolved, question in molecular biology. Using a representative set of protein-DNA complexes, we first show that our model is able to predict the interaction surface between the macromolecular partners taken in their bound for ...[more]