Ontology highlight
ABSTRACT:
SUBMITTER: Poh YC
PROVIDER: S-EPMC2905070 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Poh Yeh-Chuin YC Chowdhury Farhan F Tanaka Tetsuya S TS Wang Ning N
Biophysical journal 20100701 2
It has been previously established that living cells, including mesenchymal stem cells, stiffen in response to elevation of substrate stiffness. This stiffening is largely attributed to the elevation of the tractions at the cell base that is associated with increases in cell spreading on more-rigid substrates. We show here, surprisingly, that mouse embryonic stem cells (ESCs) do not stiffen when substrate stiffness increases. As shown recently, these cells do not increase spreading on more-rigid ...[more]