Ontology highlight
ABSTRACT:
SUBMITTER: Jackson RN
PROVIDER: S-EPMC2905245 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Jackson Ryan N RN Klauer A Alejandra AA Hintze Bradley J BJ Robinson Howard H van Hoof Ambro A Johnson Sean J SJ
The EMBO journal 20100528 13
The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for this vital function is not understood and detailed analysis is significantly limited by the lack of structural data. In this study, we present the crystal structure of Mtr4. The structure reveals a new arch-like domain that is specific to Mtr4 and Ski2 (the cytosolic homologue of Mtr4). In vivo and in vitro analyses demonstrate that the Mtr4 ...[more]