Cross-sector review of drivers and available 3Rs approaches for acute systemic toxicity testing.
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ABSTRACT:
SUBMITTER: Seidle T
PROVIDER: S-EPMC2905404 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Cross-sector review of drivers and available 3Rs approaches for acute systemic toxicity testing.
Seidle Troy T Robinson Sally S Holmes Tom T Creton Stuart S Prieto Pilar P Scheel Julia J Chlebus Magda M
Toxicological sciences : an official journal of the Society of Toxicology 20100519 2
Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to ide ...[more]
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