Ontology highlight
ABSTRACT:
SUBMITTER: Christensen BC
PROVIDER: S-EPMC2905466 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Christensen Brock C BC Houseman E Andres EA Poage Graham M GM Godleski John J JJ Bueno Raphael R Sugarbaker David J DJ Wiencke John K JK Nelson Heather H HH Marsit Carmen J CJ Kelsey Karl T KT
Cancer research 20100629 14
Development of mesothelioma is linked mainly to asbestos exposure, but the combined contributions of genetic and epigenetic alterations are unclear. We investigated the potential relationships between gene copy number (CN) alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n = 23). There were no instances of significantly correlated CN alteration and methylation at probed loci, whereas averaging loci over their associated genes revealed only two genes with signif ...[more]