Ontology highlight
ABSTRACT:
SUBMITTER: Astle JM
PROVIDER: S-EPMC2905650 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Astle John M JM Simpson Levi S LS Huang Yong Y Reddy M Muralidhar MM Wilson Rosemary R Connell Steven S Wilson Johnnie J Kodadek Thomas T
Chemistry & biology 20100101 1
Several approaches have been developed for screening combinatorial libraries or collections of synthetic molecules for agonists or antagonists of protein function, each with its own advantages and limitations. In this report, we describe an experimental platform that seamlessly couples massively parallel bead-based screening of one-bead one-compound combinatorial libraries with microarray-based quantitative comparisons of the binding affinities of the many hits isolated from the bead library. Co ...[more]