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Electrophilic aromatic selenylation: new OPRT inhibitors.

ABSTRACT: 2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

SUBMITTER: Abdo M

PROVIDER: S-EPMC2906230 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Electrophilic aromatic selenylation: new OPRT inhibitors.

Abdo Mohannad M Zhang Yong Y Schramm Vern L VL Knapp Spencer S

Organic letters 20100701 13

2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase. ...[more]

PMID: 20521773

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