Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
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ABSTRACT:
SUBMITTER: Cummins NW
PROVIDER: S-EPMC2906377 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
Cummins Nathan W NW Jiang Wei W McGinty John J Bren Gary D GD Bosch Ronald J RJ Landay Alan A Deeks Steven G SG Martin Jeffrey N JN Douek Daniel D Lederman Michael M MM Brenchley Jason J Badley Andrew D AD
The Journal of infectious diseases 20100801 3
Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell coun ...[more]
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