An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer.

ABSTRACT:

Background

Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant relapse.

Methods

We included 153 patients with stage I-II hormonal receptor-positive breast cancer. RNA was isolated from formalin-fixed paraffin-embedded samples and qRT-PCR amplification of 83 genes was performed with gene expression assays. The genes we analyzed were those included in the 70-Gene Signature, the Recurrence Score and the Two-Gene Index. The association among gene expression, clinical variables and distant metastasis-free survival was analyzed using Cox regression models.

Results

An 8-gene prognostic score was defined. Distant metastasi

SUBMITTER: Sanchez-Navarro I 

PROVIDER: S-EPMC2906483 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature