Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2906588 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Wang Xing X Zhang Xiaoping X Mao Chengde C Seeman Nadrian C NC
Proceedings of the National Academy of Sciences of the United States of America 20100628 28
DNA is found in the cell largely as a negatively supercoiled molecule. This high-energy form of the genetic material can engender sequence-dependent structures, such as cruciforms, Z-DNA, or H-DNA, even though they are not favored by conventional conditions in relaxed DNA. A key feature of DNA in living systems is the presence of homology. We have sought homology-dependent structural phenomena based on topological relaxation. Using two-dimensional electrophoresis, we demonstrate a structural tra ...[more]