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Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy.

ABSTRACT: Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.

SUBMITTER: Hu SH

PROVIDER: S-EPMC2907143 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy.

Hu Shang-Hsiu SH Gao Xiaohu X

Journal of the American Chemical Society 20100601 21

Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative applicati ...[more]

PMID: 20459132

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