Ontology highlight
ABSTRACT:
SUBMITTER: Conrad KL
PROVIDER: S-EPMC2907460 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Conrad Kelly L KL McCutcheon James E JE Cotterly Lindsay M LM Ford Kerstin A KA Beales Mitch M Marinelli Michela M
Biological psychiatry 20100521 3
<h4>Background</h4>Acute and chronic stress reinstates drug-seeking behavior. Current animal models show that these effects are contingent (temporally, contextually, or both) on the drug-conditioning environment. To date, no paradigm exists to model the common human situation in which stressors that are distinct from the experience of drugs can lead to relapse.<h4>Methods</h4>Rats were allowed to self-administer cocaine or saline over 8 days. They then underwent extinction training, during which ...[more]