Ontology highlight
ABSTRACT:
SUBMITTER: Sears RM
PROVIDER: S-EPMC2907886 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Sears Robert M RM Liu Rong-Jian RJ Narayanan Nandakumar S NS Sharf Ruth R Yeckel Mark F MF Laubach Mark M Aghajanian George K GK DiLeone Ralph J RJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100601 24
The lateral hypothalamus and the nucleus accumbens shell (AcbSh) are brain regions important for food intake. The AcbSh contains high levels of receptor for melanin-concentrating hormone (MCH), a lateral hypothalamic peptide critical for feeding and metabolism. MCH receptor (MCHR1) activation in the AcbSh increases food intake, while AcbSh MCHR1 blockade reduces feeding. Here biochemical and cellular mechanisms of MCH action in the rodent AcbSh are described. A reduction of phosphorylation of Gl ...[more]