Ontology highlight
ABSTRACT:
SUBMITTER: Jackson PJ
PROVIDER: S-EPMC2907901 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Jackson Pilgrim J PJ Douglas Nick R NR Chai Biaoxin B Binkley Jonathan J Sidow Arend A Barsh Gregory S GS Millhauser Glenn L GL
Chemistry & biology 20061201 12
Agouti (ASIP) and Agouti-related protein (AgRP) are endogenous antagonists of melanocortin receptors that play critical roles in the regulation of pigmentation and energy balance, respectively, and which arose from a common ancestral gene early in vertebrate evolution. The N-terminal domain of ASIP facilitates antagonism by binding to an accessory receptor, but here we show that the N-terminal domain of AgRP has the opposite effect and acts as a prodomain that negatively regulates antagonist fun ...[more]