Ontology highlight
ABSTRACT:
SUBMITTER: Jamieson SE
PROVIDER: S-EPMC2908187 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Jamieson S E SE Peixoto-Rangel A L AL Hargrave A C AC Roubaix L-A de LA Mui E J EJ Boulter N R NR Miller E N EN Fuller S J SJ Wiley J S JS Castellucci L L Boyer K K Peixe R G RG Kirisits M J MJ Elias L de Souza Lde S Coyne J J JJ Correa-Oliveira R R Sautter M M Smith N C NC Lees M P MP Swisher C N CN Heydemann P P Noble A G AG Patel D D Bardo D D Burrowes D D McLone D D Roizen N N Withers S S Bahia-Oliveira L M G LM McLeod R R Blackwell J M JM
Genes and immunity 20100610 5
Congenital Toxoplasma gondii infection can result in intracranial calcification, hydrocephalus and retinochoroiditis. Acquired infection is commonly associated with ocular disease. Pathology is characterized by strong proinflammatory responses. Ligation of ATP by purinergic receptor P2X(7), encoded by P2RX7, stimulates proinflammatory cytokines and can lead directly to killing of intracellular pathogens. To determine whether P2X(7) has a role in susceptibility to congenital toxoplasmosis, we exa ...[more]