Ontology highlight
ABSTRACT:
SUBMITTER: Cadwell K
PROVIDER: S-EPMC2908380 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Cell 20100601 7
It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice. This virus-plus-susceptibility gene interaction generated abnormalities in granule packaging and unique patterns of gene expression in Paneth cells. Further, the response to injury induc ...[more]