Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.
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ABSTRACT:
SUBMITTER: Bu G
PROVIDER: S-EPMC2908393 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.
Nature reviews. Neuroscience 20090402 5
The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the epsilon4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-beta peptide and by di ...[more]
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