Ontology highlight
ABSTRACT:
SUBMITTER: Duffey TA
PROVIDER: S-EPMC2908517 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Duffey Trisha A TA Mackay James A JA Vedejs Edwin E
The Journal of organic chemistry 20100701 14
Two complementary chiral catalysts, the phosphine 8d and the DMAP-derived ent-23b, are used simultaneously to selectively activate a mixture of two different achiral anhydrides as acyl donors under homogeneous conditions. The resulting activated intermediates 25 and 26 react with the racemic benzylic alcohol 5 to form enantioenriched esters (R)-24 and (S)-17 by fully catalytic parallel kinetic resolution (PKR). The aroyl ester (R)-24 is obtained with near-ideal enantioselectivity for the PKR pro ...[more]