Ontology highlight
ABSTRACT:
SUBMITTER: Bryant CM
PROVIDER: S-EPMC2908611 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Bryant Christopher M CM Albertus Daniel L DL Kim Sinae S Chen Guoan G Brambilla Christian C Guedj Mickael M Arima Chinatsu C Travis William D WD Yatabe Yasushi Y Takahashi Takashi T Brambilla Elisabeth E Beer David G DG
PloS one 20100722 7
Lung adenocarcinoma (AD) represents a predominant type of lung cancer demonstrating significant morphologic and molecular heterogeneity. We sought to understand this heterogeneity by utilizing gene expression analyses of 432 AD samples and examining associations between 27 known cancer-related pathways and the AD subtype, clinical characteristics and patient survival. Unsupervised clustering of AD and gene expression enrichment analysis reveals that cell proliferation is the most important pathw ...[more]