Ontology highlight
ABSTRACT:
SUBMITTER: McAuley JL
PROVIDER: S-EPMC2908617 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
McAuley Julie L JL Chipuk Jerry E JE Boyd Kelli L KL Van De Velde Nick N Green Douglas R DR McCullers Jonathan A JA
PLoS pathogens 20100722 7
With the recent emergence of a novel pandemic strain, there is presently intense interest in understanding the molecular signatures of virulence of influenza viruses. PB1-F2 proteins from epidemiologically important influenza A virus strains were studied to determine their function and contribution to virulence. Using 27-mer peptides derived from the C-terminal sequence of PB1-F2 and chimeric viruses engineered on a common background, we demonstrated that induction of cell death through PB1-F2 i ...[more]