Use of transdermal melatonin delivery to improve sleep maintenance during daytime.
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ABSTRACT:
SUBMITTER: Aeschbach D
PROVIDER: S-EPMC2909186 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Use of transdermal melatonin delivery to improve sleep maintenance during daytime.
Aeschbach D D Lockyer B J BJ Dijk D-J DJ Lockley S W SW Nuwayser E S ES Nichols L D LD Czeisler C A CA
Clinical pharmacology and therapeutics 20090715 4
Oral melatonin (MEL) can improve daytime sleep, but the hormone's short elimination half-life limits its use as a hypnotic in shift workers and individuals with jet lag or other sleep problems. Here we show, in healthy subjects, that transdermal delivery of MEL during the daytime can elevate plasma MEL and reduce waking after sleep onset, by promoting sleep in the latter part of an 8-h sleep opportunity. Transdermal MEL may have advantages over fast-release oral MEL in improving sleep maintenanc ...[more]
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