Ontology highlight
ABSTRACT:
SUBMITTER: Irie HY
PROVIDER: S-EPMC2909213 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Irie Hanna Y HY Shrestha Yashaswi Y Selfors Laura M LM Frye Fabianne F Iida Naoko N Wang Zhigang Z Zou Lihua L Yao Jun J Lu Yiling Y Epstein Charles B CB Natesan Sridaran S Richardson Andrea L AL Polyak Kornelia K Mills Gordon B GB Hahn William C WC Brugge Joan S JS
PloS one 20100723 7
<h4>Background</h4>Proteins that are required for anchorage-independent survival of tumor cells represent attractive targets for therapeutic intervention since this property is believed to be critical for survival of tumor cells displaced from their natural niches. Anchorage-independent survival is induced by growth factor receptor hyperactivation in many cell types. We aimed to identify molecules that critically regulate IGF-1-induced anchorage-independent survival.<h4>Methods and results</h4>W ...[more]