Ontology highlight
ABSTRACT:
SUBMITTER: Gibson JL
PROVIDER: S-EPMC2909356 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Gibson Janet L JL Lombardo Mary-Jane MJ Thornton Philip C PC Hu Kenneth H KH Galhardo Rodrigo S RS Beadle Bernadette B Habib Anand A Magner Daniel B DB Frost Laura S LS Herman Christophe C Hastings P J PJ Rosenberg Susan M SM
Molecular microbiology 20100519 2
Pathways of mutagenesis are induced in microbes under adverse conditions controlled by stress responses. Control of mutagenesis by stress responses may accelerate evolution specifically when cells are maladapted to their environments, i.e. are stressed. Stress-induced mutagenesis in the Escherichia coli Lac assay occurs either by 'point' mutation or gene amplification. Point mutagenesis is associated with DNA double-strand-break (DSB) repair and requires DinB error-prone DNA polymerase and the S ...[more]