Ontology highlight
ABSTRACT:
SUBMITTER: Amaro AC
PROVIDER: S-EPMC2909587 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Amaro Ana C AC Samora Catarina P CP Holtackers René R Wang Enxiu E Kingston Isabel J IJ Alonso Maria M Lampson Michael M McAinsh Andrew D AD Meraldi Patrick P
Nature cell biology 20100314 4
Chromosome segregation in metazoans requires the alignment of sister kinetochores on the metaphase plate. During chromosome alignment, bioriented kinetochores move chromosomes by regulating the plus-end dynamics of the attached microtubules. The bundles of kinetochore-bound microtubules alternate between growth and shrinkage, leading to regular oscillations along the spindle axis. However, the molecular mechanisms that coordinate microtubule plus-end dynamics remain unknown. Here we show that ce ...[more]