Ontology highlight
ABSTRACT:
SUBMITTER: Gyimesi M
PROVIDER: S-EPMC2910040 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Gyimesi Máté M Sarlós Kata K Kovács Mihály M
Nucleic acids research 20100308 13
BLM, one of the human RecQ helicases, plays a fundamental role in homologous recombination-based error-free DNA repair pathways, which require its translocation and DNA unwinding activities. Although translocation is essential in vivo during DNA repair processes and it provides a framework for more complex activities of helicases, including strand separation and nucleoprotein displacement, its mechanism has not been resolved for any human DNA helicase. Here, we present a quantitative model for t ...[more]