Ontology highlight
ABSTRACT:
SUBMITTER: Gheldof N
PROVIDER: S-EPMC2910055 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Gheldof Nele N Smith Emily M EM Tabuchi Tomoko M TM Koch Christoph M CM Dunham Ian I Stamatoyannopoulos John A JA Dekker Job J
Nucleic acids research 20100331 13
Identification of regulatory elements and their target genes is complicated by the fact that regulatory elements can act over large genomic distances. Identification of long-range acting elements is particularly important in the case of disease genes as mutations in these elements can result in human disease. It is becoming increasingly clear that long-range control of gene expression is facilitated by chromatin looping interactions. These interactions can be detected by chromosome conformation ...[more]