Ontology highlight
ABSTRACT:
SUBMITTER: Vasilevko V
PROVIDER: S-EPMC2910127 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Vasilevko Vitaly V Pop Viorela V Kim Hyun Jin HJ Saing Tommy T Glabe Charles C CC Milton Saskia S Barrett Edward G EG Cotman Carl W CW Cribbs David H DH Head Elizabeth E
Neurobiology of disease 20100506 3
Previously we showed that anti-Abeta peptide immunotherapy significantly attenuated Alzheimer's-like amyloid deposition in the central nervous system of aged canines. In this report we have characterized the changes that occurred in the humoral immune response over 2.4years in canines immunized repeatedly with aggregated Abeta(1-42) (AN1792) formulated in alum adjuvant. We observed a rapid and robust induction of anti-Abeta antibody titers, which were associated with an anti-inflammatory T helpe ...[more]