Ontology highlight
ABSTRACT:
SUBMITTER: Tomecki R
PROVIDER: S-EPMC2910271 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Tomecki Rafal R Tomecki Rafal R Kristiansen Maiken S MS Lykke-Andersen Søren S Chlebowski Aleksander A Larsen Katja M KM Szczesny Roman J RJ Drazkowska Karolina K Pastula Agnieszka A Andersen Jens S JS Stepien Piotr P PP Dziembowski Andrzej A Jensen Torben Heick TH
The EMBO journal 20100608 14
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Saccharomyces cerevisiae, enzymatic activity comes from the associated subunits Dis3p (Rrp44p) and Rrp6p. The former is a nuclear and cytoplasmic RNase II/R-like enzyme, which possesses both processive exo- and endonuclease activities, whereas the latter ...[more]