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Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.

ABSTRACT: The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhibitors that interact specifically with targets besides transcriptase and protease. This review presents details of the anti-HIV inhibitors discovered with computer-aided approaches and provides an overview of the recent five-year achievements in the treatment of HIV infection and the application of computational methods to current drug design.

SUBMITTER: Tan JJ

PROVIDER: S-EPMC2910421 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.

Tan Jian J JJ Cong Xiao J XJ Hu Li M LM Wang Cun X CX Jia Lee L Liang Xing-Jie XJ

Drug discovery today 20100122 5-6

The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhib ...[more]

PMID: 20096804

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