Ontology highlight
ABSTRACT:
SUBMITTER: Drewry JA
PROVIDER: S-EPMC2910512 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20091201 6
We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(ii) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity. ...[more]