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Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

ABSTRACT: Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.

SUBMITTER: Rathe JA

PROVIDER: S-EPMC2910715 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

Rathe Jennifer A JA Liu Xinyue X Tallon Luke J LJ Gern James E JE Liggett Stephen B SB

Archives of virology 20091120 1

Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have res ...[more]

PMID: 19936613

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