Whole exome capture in solution with 3 Gbp of data.
Ontology highlight
ABSTRACT:
SUBMITTER: Bainbridge MN
PROVIDER: S-EPMC2911110 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Whole exome capture in solution with 3 Gbp of data.
Bainbridge Matthew N MN Wang Min M Burgess Daniel L DL Kovar Christie C Rodesch Matthew J MJ D'Ascenzo Mark M Kitzman Jacob J Wu Yuan-Qing YQ Newsham Irene I Richmond Todd A TA Jeddeloh Jeffrey A JA Muzny Donna D Albert Thomas J TJ Gibbs Richard A RA
Genome biology 20100617 6
We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in large scale genomic studies. ...[more]
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