Ontology highlight
ABSTRACT:
SUBMITTER: Dawson PA
PROVIDER: S-EPMC2911127 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Dawson Paul A PA Hubbert Melissa L ML Rao Anuradha A
Biochimica et biophysica acta 20100609 9
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-OSTbeta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OSTalpha ...[more]