Existence of a microRNA pathway in anucleate platelets.
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ABSTRACT:
SUBMITTER: Landry P
PROVIDER: S-EPMC2911476 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Existence of a microRNA pathway in anucleate platelets.
Landry Patricia P Plante Isabelle I Ouellet Dominique L DL Perron Marjorie P MP Rousseau Guy G Provost Patrick P
Nature structural & molecular biology 20090809 9
Platelets have a crucial role in the maintenance of hemostasis as well as in thrombosis and vessel occlusion, which underlie stroke and acute coronary syndromes. Anucleate platelets contain mRNAs and are capable of protein synthesis, raising the issue of how these mRNAs are regulated. Here we show that human platelets harbor an abundant and diverse array of microRNAs (miRNAs), which are known as key regulators of mRNA translation in other cell types. Further analyses revealed that platelets cont ...[more]
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