Ontology highlight
ABSTRACT:
SUBMITTER: Desilva TM
PROVIDER: S-EPMC2911955 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Desilva Tara M TM Billiards Saraid S SS Borenstein Natalia S NS Trachtenberg Felicia L FL Volpe Joseph J JJ Kinney Hannah C HC Rosenberg Paul A PA
The Journal of comparative neurology 20080501 2
The major neuropathological correlate of cerebral palsy in premature infants is periventricular leukomalacia (PVL), a disorder of the immature cerebral white matter. Cerebral ischemia leading to excitotoxicity is thought to be important in the pathogenesis of this disorder, implying a critical role for glutamate transporters, the major determinants of extracellular glutamate concentration. Previously, we found that EAAT2 expression is limited primarily to premyelinating oligodendrocytes early in ...[more]