Angiotensin II sustains brain inflammation in mice via TGF-beta.
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ABSTRACT:
SUBMITTER: Lanz TV
PROVIDER: S-EPMC2912186 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Angiotensin II sustains brain inflammation in mice via TGF-beta.
Lanz Tobias V TV Ding Zhaoqing Z Ho Peggy P PP Luo Jian J Agrawal Ankur N AN Srinagesh Hrishikesh H Axtell Robert R Zhang Hui H Platten Michael M Wyss-Coray Tony T Steinman Lawrence L
The Journal of clinical investigation 20100712 8
The renin-angiotensin-aldosterone system (RAAS) is a key hormonal system regulating blood pressure. However, expression of RAAS components has recently been detected in immune cells, and the RAAS has been implicated in several mouse models of autoimmune disease. Here, we have identified Ang II as a paracrine mediator, sustaining inflammation in the CNS in the EAE mouse model of MS via TGF-beta. Ang II type 1 receptors (AT1Rs) were found to be primarily expressed in CNS-resident cells during EAE. ...[more]
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