Ontology highlight
ABSTRACT:
SUBMITTER: Karachi C
PROVIDER: S-EPMC2912198 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Karachi Carine C Grabli David D Bernard Frédéric A FA Tandé Dominique D Wattiez Nicolas N Belaid Hayat H Bardinet Eric E Prigent Annick A Nothacker Hans-Peter HP Hunot Stéphane S Hartmann Andreas A Lehéricy Stéphane S Hirsch Etienne C EC François Chantal C
The Journal of clinical investigation 20100712 8
Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other parkinsonian symptoms. The brain structures underlying gait disorders and falls in PD and aging remain to be characterized. Using functional MRI in healthy human subjects, we have shown here that activity of the mesencephalic locomotor region (MLR), which is composed of the pedunculopontine nucleus (PPN) and the adjacent c ...[more]