Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Porath I
PROVIDER: S-EPMC2912221 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Ben-Porath Ittai I Thomson Matthew W MW Carey Vincent J VJ Ge Ruping R Bell George W GW Regev Aviv A Weinberg Robert A RA
Nature genetics 20080501 5
Cancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear, however, whether these phenotypic similarities reflect the activity of common molecular pathways. Here, we analyze the enrichment patterns of gene sets associated with embryonic stem (ES) cell identity in the expression profiles of various human tumor types. We find that histologically poorly differentiated tumors show preferential overexpression of genes normally enriched in ES cells, combined with pr ...[more]