Ontology highlight
ABSTRACT:
SUBMITTER: Moreno D
PROVIDER: S-EPMC2912345 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Moreno Daniel D Towler Mhairi C MC Hardie D Grahame DG Knecht Erwin E Sanz Pascual P
Molecular biology of the cell 20100609 15
Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-specificity protein phosphatase, and malin, an E3-ubiquitin ligase. In this study, we report that a functional laforin-malin complex promotes the ubiquitination of AMP-activated protein kinase (AMPK), a serine/threonine protein kinase that acts as a sensor of cellular energy status. This reaction occurs when any of the three AMPK subunits (alpha, ...[more]