Ontology highlight
ABSTRACT:
SUBMITTER: Ryan S
PROVIDER: S-EPMC2912358 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ryan Sean S Verghese Susamma S Cianciola Nicholas L NL Cotton Calvin U CU Carlin Cathleen R CR
Molecular biology of the cell 20100602 15
Sorting and maintenance of the EGF receptor on the basolateral surface of renal epithelial cells is perturbed in polycystic kidney disease and apical expression of receptors contributes to severity of disease. The goal of these studies was to understand the molecular basis for EGF receptor missorting using a well-established mouse model for the autosomal recessive form of the disease. We have discovered that multiple basolateral pathways mediate EGF receptor sorting in renal epithelial cells. Th ...[more]