Discrimination of saturated aldehydes by the rat I7 olfactory receptor.
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ABSTRACT:
SUBMITTER: Kurland MD
PROVIDER: S-EPMC2912408 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Discrimination of saturated aldehydes by the rat I7 olfactory receptor.
Kurland Michael D MD Newcomer Michael B MB Peterlin Zita Z Ryan Kevin K Firestein Stuart S Batista Victor S VS
Biochemistry 20100801 30
The discrimination of n-alkyl-saturated aldehydes during the early stage of odorant recognition by the rat I7 olfactory receptor (OR-I7) is investigated. The concentrations of odorants necessary for 50% activation (or inhibition) of the OR-I7 are measured by calcium imaging recordings of dissociated rat olfactory sensory neurons, expressing the recombinant OR-I7 from an adenoviral vector. These are correlated with the corresponding binding free energies computed for a homology structural model o ...[more]
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