Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Romero MA
PROVIDER: S-EPMC2912659 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Sánchez-Romero María Antonia MA Busby Stephen J W SJ Dyer Nigel P NP Ott Sascha S Millard Andrew D AD Grainger David C DC
mBio 20100518 1
The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which binds to multiple hemi-methylated GATC sequences immediately after replication has initiated. This sequesters oriC, thereby preventing reinitiation of replication. However, the genome-wide DNA binding properties of SeqA are unknown, and hence, he ...[more]