Dataset Information

Laterality of amblyopia.

ABSTRACT:

Purpose

To determine the frequency of unilateral amblyopia in right versus left eyes among children younger than 18 years.

Design

Analysis of data collected in randomized clinical trials conducted by the Pediatric Eye Disease Investigator Group.

Methods

The laterality of the amblyopic eye was analyzed in 2635 subjects younger than 18 years who participated in 9 multicenter prospective, randomized treatment trials. Eligibility criteria for these clinical trials included unilateral amblyopia associated with strabismus, anisometropia, or both, with visual acuity between 20/40 and 20/400. Logistic regression was used to assess the association of baseline and demographic factors with the laterality of amblyopia.

Results

Among subjects with anisometropic amblyopia (with or without strabismus), amblyopia was present more often in left than right eyes, with a relative prevalence of 59% in left eyes (95% confidence interval, 57% to 62%; P < .001 from a test of proportion, 50%). However, among subjects with strabismic-only amblyopia, there was no laterality predilection (relative prevalence of 50% in left eyes; 95% confidence interval, 47% to 54%; P = .94).

Conclusions

Anisometropic amblyopia, with or without strabismus, occurs more often in left eyes than right eyes. This finding of amblyopia laterality may be related to microtropia, sighting dominance, or other forms of ocular dominance; developmental or neurological factors; laterality in the development of refractive error; or a combination thereof.

SUBMITTER: Repka M

PROVIDER: S-EPMC2912965 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Publications

Laterality of amblyopia.

Repka Michael M Simons Kurt K Kraker Raymond R

American journal of ophthalmology 20100508 2

<h4>Purpose</h4>To determine the frequency of unilateral amblyopia in right versus left eyes among children younger than 18 years.<h4>Design</h4>Analysis of data collected in randomized clinical trials conducted by the Pediatric Eye Disease Investigator Group.<h4>Methods</h4>The laterality of the amblyopic eye was analyzed in 2635 subjects younger than 18 years who participated in 9 multicenter prospective, randomized treatment trials. Eligibility criteria for these clinical trials included unil ...[more]

PMID: 20451898

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Project description:BackgroundStimulus deprivation amblyopia (SDA) develops due to an obstruction to the passage of light secondary to a condition such as cataract. The obstruction prevents formation of a clear image on the retina. SDA can be resistant to treatment, leading to poor visual prognosis. SDA probably constitutes less than 3% of all amblyopia cases, although precise estimates of prevalence are unknown. In high-income countries, most people present under the age of one year; in low- to middle-income countries, people are likely to be older at the time of presentation. The mainstay of treatment is correction of the obstruction (e.g., removal of the cataract) and then occlusion of the better-seeing eye, but regimens vary, can be difficult to execute, and traditionally are believed to lead to disappointing results.ObjectivesTo evaluate the effectiveness of occlusion therapy for SDA in an attempt to establish realistic treatment outcomes and to examine evidence of any dose-response effect and assess the effect of the duration, severity, and causative factor on the size and direction of the treatment effect.Search methodsWe searched CENTRAL (2018, Issue 12), which contains the Cochrane Eyes and Vision Trials Register; Ovid MEDLINE; Embase.com; and five other databases. We used no date or language restrictions in the electronic searches. We last searched the databases on 12 December 2018.Selection criteriaWe planned to include randomized controlled trials (RCTs) and controlled clinical trials of participants with unilateral SDA with visual acuity worse than 0.2 LogMAR or equivalent. We specified no restrictions for inclusion based upon age, gender, ethnicity, comorbidities, medication use, or the number of participants.Data collection and analysisWe used standard Cochrane methodology.Main resultsWe identified no trials that met the inclusion criteria specified in the protocol for this review.Authors' conclusionsWe found no evidence from RCTs or quasi-randomized trials on the effectiveness of any treatment for SDA. RCTs are needed in order to evaluate the safety and effectiveness of occlusion, duration of treatment, level of vision that can be realistically achieved, effects of age at onset and magnitude of visual defect, optimum occlusion regimen, and factors associated with satisfactory and unsatisfactory outcomes with the use of various interventions for SDA.

Dataset Information

Laterality of amblyopia.

Purpose

Design

Methods

Results

Conclusions

Publications

Laterality of amblyopia.

Similar Datasets

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