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Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis.


ABSTRACT:

Context

Adipose tissue in obese individuals is characterized by reduced capillary density and reduced oxygenation.

Objective

Our objective was to test whether hypoxia is associated with reduced antilipolytic effect of insulin.

Participants, design, and setting

Twenty-one lean and obese individuals participated in this cross-sectional study at a university-based clinical research center.

Intervention

In all subjects, in situ adipose tissue (AT) oxygenation [AT oxygen partial pressure (ATpO2)] was measured with a Clark electrode, insulin sensitivity as well as basal and insulin-suppressed lipolysis (continuous infusion of (2H5)glycerol) were measured during a euglycemic-hyperinsulinemic clamp, and abdominal sc AT biopsies were collected to assess fat cell size (Coulter counting of osmium-fixed cells), capillary density (by staining of histological sections), and gene expression (by quantitative RT-PCR).

Main outcome measure

In situ ATpO2 was evaluated.

Results

The ability of insulin to suppress lipolysis (percent) was positively correlated with insulin sensitivity (r=0.43; P<0.05), ATpO2 (r=0.44; P<0.05), vascular endothelial growth factor mRNA (r=0.73; P<0.01), and capillary density (r=0.75; P<0.01).

Conclusion

These results indicate that low capillary density and ATpO2 in AT are potentially upstream causes of AT dysfunction.

SUBMITTER: Pasarica M 

PROVIDER: S-EPMC2913036 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Publications

Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis.

Pasarica Magdalena M   Rood Jennifer J   Ravussin Eric E   Schwarz Jean-Marc JM   Smith Steven R SR   Redman Leanne M LM  

The Journal of clinical endocrinology and metabolism 20100513 8


<h4>Context</h4>Adipose tissue in obese individuals is characterized by reduced capillary density and reduced oxygenation.<h4>Objective</h4>Our objective was to test whether hypoxia is associated with reduced antilipolytic effect of insulin.<h4>Participants, design, and setting</h4>Twenty-one lean and obese individuals participated in this cross-sectional study at a university-based clinical research center.<h4>Intervention</h4>In all subjects, in situ adipose tissue (AT) oxygenation [AT oxygen  ...[more]

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