Ontology highlight
ABSTRACT:
SUBMITTER: Bhat VT
PROVIDER: S-EPMC2913121 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Bhat Venugopal T VT Caniard Anne M AM Luksch Torsten T Brenk Ruth R Campopiano Dominic J DJ Greaney Michael F MF
Nature chemistry 20100516 6
Dynamic covalent chemistry uses reversible chemical reactions to set up an equilibrating network of molecules at thermodynamic equilibrium, which can adjust its composition in response to any agent capable of altering the free energy of the system. When the target is a biological macromolecule, such as a protein, the process corresponds to the protein directing the synthesis of its own best ligand. Here, we demonstrate that reversible acylhydrazone formation is an effective chemistry for biologi ...[more]