Ontology highlight
ABSTRACT:
SUBMITTER: Jiarpinitnun C
PROVIDER: S-EPMC2913153 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Jiarpinitnun Chutima C Kiessling Laura L LL
Journal of the American Chemical Society 20100701 26
Polyethylene glycol (PEG) is widely used, and many biologically active molecules are modified with oligoethylene glycol substituents to enhance their half-lives in circulation. The pervasive use of PEG substituents is partly due to their presumed inertness. Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLF) to activate signal t ...[more]